Modulating immune responses to AAV by expanded polyclonal T-regs and capsid specific chimeric antigen receptor T-regulatory cells
Immune responses to adeno-associated virus (AAV) capsids limit the therapeutic potential of AAV gene therapy. Herein, we model clinical immune responses by generating AAV capsid-specific chimeric antigen receptor (AAV-CAR) T cells. We then modulate immune responses to AAV capsid with AAV-CAR regulatory T cells (Tregs). AAV-CAR Tregs in vitro display phenotypical Treg surface marker expression, and functional suppression of effector T cell proliferation and cytotoxicity.
In mouse models, AAV-CAR Tregs mediated continued transgene expression from an immunogenic capsid, despite antibody responses, produced immunosuppressive cytokines, and decreased tissue inflammation. AAV-CAR Tregs are also able to bystander suppress immune responses to immunogenic transgenes similarly mediating continued transgene expression, producing immunosuppressive cytokines, and reducing tissue infiltration. Taken together, AAV-CAR T cells and AAV-CAR Tregs are directed and powerful immunosuppressive tools to model and modulate immune responses to AAV capsids and transgenes in the local environment.
Valutazione non clinica della sicurezza e biodistribuzione in vivo di CoviFab, un frammento F (ab ‘) 2 specifico per RBD derivato da anticorpi policlonali equini
Aptameri policlonali per l’etichettatura a fluorescenza specifica e la quantificazione del batterio intestinale umano rilevante per la salute Parabacteroides distasonis
Preparazione e identificazione dell’anticorpo policlonale di ratto contro la proteasi principale SARS-CoV-2 (Mpro)
Produzione e caratterizzazione di anticorpi policlonali e monoclonali della proteina poriforme della lampreda
Polyclonal PPARG polyclonal antibody |
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AMR09486G | Leading Biology | 0.05mg | 633.6 EUR |
Polyclonal FKBP51 polyclonal antibody |
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APR15992G | Leading Biology | 0.1ml | 580.8 EUR |
Polyclonal PIWIL2 polyclonal antibody |
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APR17846G | Leading Biology | 0.1ml | 580.8 EUR |
Polyclonal ACTL6B polyclonal antibody |
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AMM05547G | Leading Biology | 0.1ml | 580.8 EUR |
Polyclonal JARID2 polyclonal antibody |
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AMM06027G | Leading Biology | 0.05ml | 580.8 EUR |
Polyclonal JMJD2c polyclonal antibody |
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APR00375G | Leading Biology | 0.05ml | 580.8 EUR |
Polyclonal JMJD2c polyclonal antibody |
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APR00450G | Leading Biology | 0.1ml | 580.8 EUR |
Polyclonal LYDG10 polyclonal antibody |
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APR00456G | Leading Biology | 0.1ml | 580.8 EUR |
Polyclonal JARID2 polyclonal antibody |
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APR12450G | Leading Biology | 0.1ml | 580.8 EUR |
Polyclonal ZMYND8 polyclonal antibody |
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AMM08559G | Leading Biology | 0.1ml | 580.8 EUR |
Polyclonal AKR1B10 Polyclonal Antibody |
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APG01659G | Leading Biology | 0.1mg | 580.8 EUR |
Polyclonal p53K372me1 polyclonal antibody |
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APR00440G | Leading Biology | 0.05mg | 633.6 EUR |
Polyclonal FGF-1 Polyclonal Antibody |
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APR00423G | Leading Biology | 0.1mg | 580.8 EUR |
polyclonal antibodyPN1 polyclonal antibody |
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BZ16794 | Bioworld Biotech | 50ul | 358 EUR |
Polyclonal AntibodyPC1 Polyclonal Antibody |
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E-AB-65139-120uL | Elabscience Biotech | 120uL | 320 EUR |
Polyclonal AntibodyPC1 Polyclonal Antibody |
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E-AB-65139-200uL | Elabscience Biotech | 200uL | 530 EUR |
Polyclonal AntibodyPC1 Polyclonal Antibody |
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E-AB-65139-60uL | Elabscience Biotech | 60uL | 200 EUR |
Polyclonal AntibodyPC1 Polyclonal Antibody |
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E-AB-65139-each | Elabscience Biotech | each | Ask for price |
Polyclonal AntibodyPC1 Polyclonal Antibody |
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RD81942A-120uL | Reddot Biotech | 120μL | 360 EUR |
Polyclonal AntibodyPC1 Polyclonal Antibody |
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RD81942A-200uL | Reddot Biotech | 200μL | 630 EUR |
Polyclonal AntibodyPC1 Polyclonal Antibody |
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RD81942A-60uL | Reddot Biotech | 60μL | 204 EUR |
Polyclonal AntibodyPC4 Polyclonal Antibody |
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RD83593A-120uL | Reddot Biotech | 120μL | 360 EUR |
Polyclonal AntibodyPC4 Polyclonal Antibody |
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RD83593A-200uL | Reddot Biotech | 200μL | 630 EUR |
Polyclonal AntibodyPC4 Polyclonal Antibody |
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RD83593A-60uL | Reddot Biotech | 60μL | 204 EUR |
Polyclonal RFX-AP polyclonal antibody |
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APR00441G | Leading Biology | 0.05mg | 633.6 EUR |
Polyclonal EIF2C1/2 polyclonal antibody |
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APR00453G | Leading Biology | 0.1ml | 580.8 EUR |
Polyclonal TGF-beta3 Polyclonal Antibody |
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APG00008G | Leading Biology | 0.1mg | 580.8 EUR |
Polyclonal sRANK Ligand Polyclonal Antibody |
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APR00294G | Leading Biology | 0.1mg | 580.8 EUR |
Polyclonal Smc3K112/113ac polyclonal antibody |
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APR00454G | Leading Biology | 0.1ml | 580.8 EUR |
Polyclonal AntibodyP2 Rabbit Polyclonal Antibody |
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ES10016-100ul | ELK Biotech | 100ul | 124 EUR |
Polyclonal AntibodyP2 Rabbit Polyclonal Antibody |
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ES10016-50ul | ELK Biotech | 50ul | 74 EUR |
Polyclonal AntibodyP4 Rabbit Polyclonal Antibody |
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ES10017-100ul | ELK Biotech | 100ul | 124 EUR |
Polyclonal AntibodyP4 Rabbit Polyclonal Antibody |
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ES10017-50ul | ELK Biotech | 50ul | 74 EUR |
Polyclonal AntibodyP5 Rabbit Polyclonal Antibody |
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ES4829-100ul | ELK Biotech | 100ul | 124 EUR |
Polyclonal AntibodyP5 Rabbit Polyclonal Antibody |
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ES4829-50ul | ELK Biotech | 50ul | 74 EUR |
Polyclonal AntibodyP3 Rabbit Polyclonal Antibody |
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ES6454-100ul | ELK Biotech | 100ul | 124 EUR |
Polyclonal AntibodyP3 Rabbit Polyclonal Antibody |
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ES6454-50ul | ELK Biotech | 50ul | 74 EUR |
Polyclonal AntibodyP1 Rabbit Polyclonal Antibody |
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ES11752-100ul | ELK Biotech | 100ul | 124 EUR |
Polyclonal AntibodyP1 Rabbit Polyclonal Antibody |
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ES11752-50ul | ELK Biotech | 50ul | 74 EUR |
Polyclonal Runx1/AML1-ETO polyclonal antibody |
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APR00371G | Leading Biology | 0.05ml | 580.8 EUR |
Rabbit polyclonal anti-IL-19 Polyclonal antibody |
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TA319096 | Origene Technologies GmbH | 100 µg | Ask for price |
Rabbit Polyclonal AntibodyPC4 Rabbit Polyclonal Antibody |
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54946 | SAB | 100ul | 439 EUR |
Rabbit Polyclonal AntibodyPC1 Rabbit Polyclonal Antibody |
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53940 | SAB | 100ul | 439 EUR |
Rabbit Polyclonal Anti-LPP rabbit polyclonal antibody |
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TA351364 | Origene Technologies GmbH | 100 µl | Ask for price |
Rabbit Polyclonal Anti-TPR rabbit polyclonal antibody |
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TA351467 | Origene Technologies GmbH | 100 µl | Ask for price |
Rabbit Polyclonal Anti-NOX5 rabbit polyclonal antibody |
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TA350234 | Origene Technologies GmbH | 100 µl | Ask for price |
Rabbit Polyclonal Anti-SRPX rabbit polyclonal antibody |
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TA350419 | Origene Technologies GmbH | 100 µl | Ask for price |
Rabbit Polyclonal Anti-STX7 rabbit polyclonal antibody |
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TA350469 | Origene Technologies GmbH | 100 µl | Ask for price |
Rabbit Polyclonal Anti-STX8 rabbit polyclonal antibody |
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TA350470 | Origene Technologies GmbH | 100 µl | Ask for price |
Rabbit Polyclonal Anti-RORA rabbit polyclonal antibody |
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TA351609 | Origene Technologies GmbH | 100 µl | Ask for price |