Modulating immune responses to AAV by expanded polyclonal T-regs and capsid specific chimeric antigen receptor T-regulatory cells
Immune responses to adeno-associated virus (AAV) capsids limit the therapeutic potential of AAV gene therapy. Herein, we model clinical immune responses by generating AAV capsid-specific chimeric antigen receptor (AAV-CAR) T cells. We then modulate immune responses to AAV capsid with AAV-CAR regulatory T cells (Tregs). AAV-CAR Tregs in vitro display phenotypical Treg surface marker expression, and functional suppression of effector T cell proliferation and cytotoxicity.
In mouse models, AAV-CAR Tregs mediated continued transgene expression from an immunogenic capsid, despite antibody responses, produced immunosuppressive cytokines, and decreased tissue inflammation. AAV-CAR Tregs are also able to bystander suppress immune responses to immunogenic transgenes similarly mediating continued transgene expression, producing immunosuppressive cytokines, and reducing tissue infiltration. Taken together, AAV-CAR T cells and AAV-CAR Tregs are directed and powerful immunosuppressive tools to model and modulate immune responses to AAV capsids and transgenes in the local environment.
Valutazione non clinica della sicurezza e biodistribuzione in vivo di CoviFab, un frammento F (ab ‘) 2 specifico per RBD derivato da anticorpi policlonali equini
Aptameri policlonali per l’etichettatura a fluorescenza specifica e la quantificazione del batterio intestinale umano rilevante per la salute Parabacteroides distasonis
Preparazione e identificazione dell’anticorpo policlonale di ratto contro la proteasi principale SARS-CoV-2 (Mpro)
Produzione e caratterizzazione di anticorpi policlonali e monoclonali della proteina poriforme della lampreda
Polyclonal Spt16 polyclonal antibody |
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APR00460G | Leading Biology | 0.05mg | 580.8 EUR |
Polyclonal ACTL6B polyclonal antibody |
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AMM05547G | Leading Biology | 0.1ml | 580.8 EUR |
Polyclonal JARID2 polyclonal antibody |
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AMM06027G | Leading Biology | 0.05ml | 580.8 EUR |
Polyclonal ZMYND8 polyclonal antibody |
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AMM08559G | Leading Biology | 0.1ml | 580.8 EUR |
Polyclonal JARID2 polyclonal antibody |
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APR12450G | Leading Biology | 0.1ml | 580.8 EUR |
Polyclonal FKBP51 polyclonal antibody |
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APR15992G | Leading Biology | 0.1ml | 580.8 EUR |
Polyclonal PIWIL2 polyclonal antibody |
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APR17846G | Leading Biology | 0.1ml | 580.8 EUR |
Polyclonal JMJD2c polyclonal antibody |
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APR00375G | Leading Biology | 0.05ml | 580.8 EUR |
Polyclonal JMJD2c polyclonal antibody |
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APR00450G | Leading Biology | 0.1ml | 580.8 EUR |
Polyclonal LYDG10 polyclonal antibody |
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APR00456G | Leading Biology | 0.1ml | 580.8 EUR |
Polyclonal AKR1B10 Polyclonal Antibody |
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APG01659G | Leading Biology | 0.1mg | 580.8 EUR |
Polyclonal FGF-1 Polyclonal Antibody |
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APR00423G | Leading Biology | 0.1mg | 580.8 EUR |
Polyclonal p53K372me1 polyclonal antibody |
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APR00440G | Leading Biology | 0.05mg | 633.6 EUR |
Polyclonal AntibodyP2 Polyclonal Antibody |
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ES10016-100ul | ELK Biotech | 100ul | 334.8 EUR |
Polyclonal AntibodyP2 Polyclonal Antibody |
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ES10016-50ul | ELK Biotech | 50ul | 248.4 EUR |
Polyclonal AntibodyP4 Polyclonal Antibody |
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ES10017-100ul | ELK Biotech | 100ul | 334.8 EUR |
Polyclonal AntibodyP4 Polyclonal Antibody |
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ES10017-50ul | ELK Biotech | 50ul | 248.4 EUR |
Polyclonal AntibodyP5 Polyclonal Antibody |
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ES4829-100ul | ELK Biotech | 100ul | 334.8 EUR |
Polyclonal AntibodyP5 Polyclonal Antibody |
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ES4829-50ul | ELK Biotech | 50ul | 248.4 EUR |
Polyclonal AntibodyP1 Polyclonal Antibody |
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ES11752-100ul | ELK Biotech | 100ul | 334.8 EUR |
Polyclonal AntibodyP1 Polyclonal Antibody |
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ES11752-50ul | ELK Biotech | 50ul | 248.4 EUR |
Polyclonal AntibodyP3 Polyclonal Antibody |
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ES6454-100ul | ELK Biotech | 100ul | 334.8 EUR |
Polyclonal AntibodyP3 Polyclonal Antibody |
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ES6454-50ul | ELK Biotech | 50ul | 248.4 EUR |
Polyclonal RFX-AP polyclonal antibody |
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APR00441G | Leading Biology | 0.05mg | 633.6 EUR |
Polyclonal EIF2C1/2 polyclonal antibody |
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APR00453G | Leading Biology | 0.1ml | 580.8 EUR |
Polyclonal TGF-beta3 Polyclonal Antibody |
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APG00008G | Leading Biology | 0.1mg | 580.8 EUR |
Polyclonal sRANK Ligand Polyclonal Antibody |
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APR00294G | Leading Biology | 0.1mg | 580.8 EUR |
Polyclonal Smc3K112/113ac polyclonal antibody |
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APR00454G | Leading Biology | 0.1ml | 580.8 EUR |
Polyclonal Runx1/AML1-ETO polyclonal antibody |
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APR00371G | Leading Biology | 0.05ml | 580.8 EUR |
Polyclonal BMF |
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APR00068G | Leading Biology | 0.1mg | 580.8 EUR |
p27 (Phospho-Ser10) Polyclonal Polyclonal Conjugated Antibody |
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C12213 | SAB | 100ul | 476.4 EUR |
PBK (Phospho-Thr9) Polyclonal Polyclonal Conjugated Antibody |
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C12233 | SAB | 100ul | 476.4 EUR |
Rb (Phospho-Thr826) Polyclonal Polyclonal Conjugated Antibody |
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C12274 | SAB | 100ul | 476.4 EUR |
Chk1 (Phospho-Ser317) Polyclonal Polyclonal Conjugated Antibody |
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C12190 | SAB | 100ul | 476.4 EUR |
Neu (Phospho-Tyr1248) Polyclonal Polyclonal Conjugated Antibody |
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C12210 | SAB | 100ul | 476.4 EUR |
NF2 (Phospho-Ser518) Polyclonal Polyclonal Conjugated Antibody |
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C12211 | SAB | 100ul | 476.4 EUR |
Op18 (Phospho-Ser16) Polyclonal Polyclonal Conjugated Antibody |
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C12212 | SAB | 100ul | 476.4 EUR |
SGK1 (Phospho-Ser422) Polyclonal Polyclonal Conjugated Antibody |
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C12220 | SAB | 100ul | 476.4 EUR |
Btk (Phospho-Tyr551) Polyclonal Polyclonal Conjugated Antibody |
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C12223 | SAB | 100ul | 476.4 EUR |
SGK1 (Phospho-Ser78) Polyclonal Polyclonal Conjugated Antibody |
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C12234 | SAB | 100ul | 476.4 EUR |
Ron (Phospho-Ser1394) Polyclonal Polyclonal Conjugated Antibody |
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C12239 | SAB | 100ul | 476.4 EUR |
Cdk9 (Phospho-Thr186) Polyclonal Polyclonal Conjugated Antibody |
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C12242 | SAB | 100ul | 476.4 EUR |
Eg5 (Phospho-Thr926) Polyclonal Polyclonal Conjugated Antibody |
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C12244 | SAB | 100ul | 476.4 EUR |
Neu (Phospho-Tyr1112) Polyclonal Polyclonal Conjugated Antibody |
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C12253 | SAB | 100ul | 476.4 EUR |
Tak1 (Phospho-Thr187) Polyclonal Polyclonal Conjugated Antibody |
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C12255 | SAB | 100ul | 476.4 EUR |
VCP (Phospho-Ser352) Polyclonal Polyclonal Conjugated Antibody |
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C12263 | SAB | 100ul | 476.4 EUR |
Flg (Phospho-Tyr654) Polyclonal Polyclonal Conjugated Antibody |
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C12267 | SAB | 100ul | 476.4 EUR |
Brk (Phospho-Tyr447) Polyclonal Polyclonal Conjugated Antibody |
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C12268 | SAB | 100ul | 476.4 EUR |
ACCα (Phospho-Ser80) Polyclonal Polyclonal Conjugated Antibody |
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C12284 | SAB | 100ul | 476.4 EUR |
HSL (Phospho-Ser855) Polyclonal Polyclonal Conjugated Antibody |
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C12287 | SAB | 100ul | 476.4 EUR |